NLRP3 inflammasome exacerbates dietary-induced insulin resistance, immune dysregulation, plaque growth and vascular remodeling, whereas a series of aging-associated metabolic dysregulations in adipose tissue, such as impaired glycaemic control, increased visceral adiposity and reduced lipolysis, are also exacerbated by the NLRP3 inflammasome. Here, NLRP3 is linked to Insulin resistance.