Dietary saturated fatty acids (SFAs), whose intake is strongly associated with an increased risk of obesity, have been identified as potent priming agents of the NLRP3 inflammasome via TLR4 in DCs, resulting in elevated expression of pro-IL-1β, caspase-1, TLR4 and NLRP3 [60]. The gene discussed is CASP1; the disease is obesity due to melanocortin 4 receptor deficiency.