The NLRP3 inflammasome impairs insulin sensitivity in dietary-induced obesity via the disruption of phosphatidylinositol 3-kinase-protein kinase B (PI3K-Akt) signaling, a major pathway orchestrating the metabolic effects of insulin in peripheral tissue [19,32,109]. This evidence concerns the gene NLRP3 and obesity due to melanocortin 4 receptor deficiency.