In a review of glioblastoma Rho-GTPase signaling, Fortin Ensign et al. discuss the role of RAC1 and its associated upstream GEFs in contributing to tumor progression and a pro-survival phenotype of glioblastoma cells via the downstream activation of the Bcl-2 family (through AKT2) and the RAC1 upregulation of downstream NF-κB [7]. Here, AKT2 is linked to glioblastoma.