Yoon et al. reported in gastric adenocarcinoma cells the potential of the PI3K pathway’s influence as an upstream regulator in a PI3K/AKT/RAC1/JNK axis, citing evidence through various inhibition assays that the upregulation of the axis promotes EMT, invasion, and chemotherapy resistance phenotypes [46]. The gene discussed is RAC1; the disease is gastric adenocarcinoma.