Compounds 80, 81, and 87 showed cytotoxic activities towards human colon adenocarcinoma cell line and were P-glycoprotein substrates, while compounds 74, 59, 86, 82, 58, and 485 were P-glycoprotein inhibitors and were capable of reversing multi-drug resistance [34]. The gene discussed is ABCB1; the disease is colon adenocarcinoma.