Pasquale et al. have reported that alleles of CDKN2BAS1 single nucleotide polymorphisms, which influence the risk of developing POAG, may also have a significant impact on optic nerve degeneration among POAG individuals, which indicates an important role of CDKN2BAS1 in POAG pathogenesis [202]. The gene discussed is CDKN2B-AS1; the disease is open-angle glaucoma.