Variants of genes with common frequency and low effect size leading to the development of POAG include the following: Cyclin-dependent kinase inhibitor 2B (CDKN2BAS), caveolin 1 and caveolin 2 (CAV1/CAV2), sine oculis homeobox homolog 1 and sine oculis homeobox homolog 6 (SIX1/SIX6), transmembrane and coiled-coil domains 1 (TMCO1), growth arrest specific 7 (GAS7), atonal homolog 7 (ATOH7), and RPGR Interacting Protein 1 (RPGRIP1) [88,91,99,100,101,102,103,104,105,106,107]. The gene discussed is CAV1; the disease is open-angle glaucoma.