TBK1 and open-angle glaucoma: Variants of genes with rare frequency and high effect size, which lead to the development of POAG include myocilin (MYOC), WD repeat domain 36 (WDR36), optineurin (OPTN), TANK-binding kinase 1 (TBK1), as well as neurotrophin 4 (NTF4) [42,88,93,94,95,96,97,98].