Interestingly, it has been demonstrated that abnormalities in WDR36 alone are not sufficient for POAG development, whereas correlation of WDR36 sequence variants with more severe disease in POAG patients suggests that abnormalities in the WDR36 may lead to POAG development, and also that WDR36 may constitute glaucoma modifier gene [125]. This evidence concerns the gene WDR36 and glaucoma.