GAS7 may interact with other genes implicated in glaucoma pathogenesis such as MYOC, OPTN, WDR36, CAV1, nitric oxide synthase 2 (NOS2), forkhead box C1 (FOXC1), apolipoprotein E (APOE), amyloid precursor protein (APP), and clusterin (CLU) [106]. The gene discussed is OPTN; the disease is glaucoma.