CAV1 and open-angle glaucoma: Caveolins inhibit endothelial nitric oxide synthase activity in the caveolae, which may evoke significant changes in vascular tone and TM function, which are closely associated with POAG pathogenesis [215,216,217,218,219] It has also been reported that caveolin 1 plays a major role in the IOP maintenance via modulation of aqueous humor drainage from the eye.