Furthermore, we observed a significant correlation between total cMet and total EGFR (p = 0.03) and the EGFR homodimer (p = 0.03), as well as between activated cMet and total EGFR (Figure 2B), suggesting cross-talk between these two pathways in cetuximab-resistant HNSCC. This evidence concerns the gene MET and head and neck squamous cell carcinoma.