To determine whether the absence of HTATIP2 expression modulates tumor cell adaptation to hypoxia, stable non-target (A549shNT) and HTATIP2-knockdown (A549shHTATIP2) A549 cell lines were generated by transducing A549 cells with a non-target shRNA and a HTATIP2-specific shRNA, respectively, through lentiviral infection. This evidence concerns the gene HTATIP2 and neoplasm.