To explore the molecular mechanism involved in the modulatory effect of the absence of HTATIP2 expression on tumor adaptation to hypoxic microenvironment with and without sorafenib treatment, the expression levels of important mediators and effectors in hypoxia-elicited pathways in the A549 and A549shHTATIP2 tumor samples using immunoblot and real-time PCR analyses were examined (Figure 6 and Figures S2 and S3). Here, HTATIP2 is linked to neoplasm.