Given the emerging evidence of the association of low HTATIP2 protein expression with high risk of metastasis and poor prognosis in NSCLC [81], by elucidating the distinct role of HTATIP2 in orchestrating tumor adaptation to hypoxic stress, the present study sets the groundwork for further attempts to identify new targets for therapeutic intervention in HTATIP2-deficient NSCLC. Here, HTATIP2 is linked to non-small cell lung carcinoma.