TTP has been shown to directly regulate EMT regulators, including ZEB1 (zinc finger E-box binding homeobox 1), SOX9 (sex-determining region Y box 9), and MACC1 (metastasis associated in colon cancer 1), all of which are known to be downregulated in colorectal carcinomas (CRC). This evidence concerns the gene MACC1 and colorectal carcinoma.