LIN28A and colonic neoplasm: Interestingly, resveratrol (3,5,4′-trihydroxystilbene), a naturally occurring polyphenol compound found in natural sources, including grape skin and red wine, was shown to activate TTP, resulting in downregulation of E2F1, inhibitor of apoptosis 2 (cIAP2), large tumor suppressor kinase 2 (LATS2), and lin-28 homolog A (Lin28)—all downstream targets of TTP—thus suppressing the proliferation and invasion/metastasis of colon cancer cells [39].