To further evaluate whether markers of neutrophil activation combined with miRNAs improved the predictive ability of the individual models in glioma patients, we adjusted a new comprehensive elastic net model that included MPO and miR-140-3p as predictors, achieving an AUC of 0.79 (95% CI [0.64, 0.94], p = 0.002). This evidence concerns the gene MPO and glioma.