Possible causes of the controversies are: hotspot, missense TP53 GOF mutants were—perhaps only by negligence—not shown to be decisive components of the multistep carcinogenesis in human normal cells models in vitro (only truncated p53 DN mutants or WT p53 inhibition were used) [4,6,7,17,18,19] and there are specific neoplasia models which, for reasons yet unknown, do not show GOF of missense TP53 mutants [20,21]. The gene discussed is TP53; the disease is neoplasm.