Overexpression of PSME3 in cancers influences the stability of CMYC, however the published results are contradictory: high levels of PSME3 inhibited CMYC degradation in pancreatic cancer cells [135], whereas studies performed in cell lines showed that PA28γ promotes CMYC degradation [136]. The gene discussed is PSME3; the disease is familial pancreatic carcinoma.