TP53 and cancer: Due to these p53 properties mutations in the TP53 gene in the context of cancer may lead to three events: loss of function (LOF) of WT p53 tumor suppressor protein which mainly involves loss of transcription factor activity, and—especially in the case of prevalent missense mutations—dominant-negative effect over WT p53 (DN) in a tetrameric protein and gain-of-function (GOF) which can actively drive neoplasia [11,12].