These signaling routes involve JNK-mediated AP-1 activation [202,203] or NFAT transcription factor induction by calcium and a Calcineurin (CaN)-mediated mechanism [204,205] However, the WNT non-canonical signaling routes were mainly described outside of the neoplasia context, requiring further assessment as drivers of neoplastic phenotypes [188]. The gene discussed is FOS; the disease is neoplasm.