The primary role of the proteasome machinery in neoplasia is postulated to be the increased degradation of tumor suppressor proteins, such as p21, p27, p53, PUMA, NOXA or IκB inhibitor of the NF-κB pathway [122] while maintaining a general protein homeostasis and oxidized protein cleanup in rapidly proliferating cells [123]. This evidence concerns the gene NFKB1 and neoplasm.