MAVS and viral infectious disease: Amongst others, LRPPRC is implicated in mitochondrial RNA metabolism acting as an RNA-chaparone for the mitochondrial transcriptome [69], is reported to be a restriction factor for autophagy, mitophagy and apoptosis [70] and was recently described to be a negative regulator of the mitochondrial antiviral signaling protein (MAVS) during viral infection [71].