Our study showed that (1) dry eye and related ocular surface damage developed after one year of aging in a C57BL/6 male mouse model, (2) inflammation of the LGs was evident after one year of aging with a consistent increase of the focus score and CD4 + IFNγ+ cells, (3) atrophy of the MGs was evident after two years of aging, (4) oxidative stress was significantly increased in both glands after two years of aging, and (5) senescence of the stem cells was not evident in either gland. The gene discussed is CD4; the disease is dry eye syndrome.