SCN3A and diabetic neuropathy: Indeed, shRNA-mediated knockdown of NaV1.3 in DRG neurons attenuates the development of mechanical allodynia in rodent models of spared nerve injury (SNI) and diabetic neuropathy [7,8], while global NaV1.3 knockout has confounding results, with minimal effect on the development of mechanical allodynia following chronic constriction injury (CCI), spinal nerve transection (SNT), and spinal nerve ligation (SNL) [9,10].