As expected, a positive relationship between CD8 and B7-H3 (r = 0.19, P = 3.07 × 10-4) or CD8 and CD47 (r = 0.23, P = 1.42 × 10-5) was observed (Figure 3A and 3B), indicating that the increased CD8+ T cells may have upregulated the adaptive immune resistant genes by activating IFNγ pathway in HCC patients. The gene discussed is CD276; the disease is hepatocellular carcinoma.