Accordingly, the positive correlation between B7-H3 expression and CD8 expression or Th1/IFNγ gene signature in our study implies that compensatory B7-H3 upregulation in HCC is induced as a result of an anti-tumor T cell response and patients with different expression patterns of B7-H3/CD8 have significantly different survivals. The gene discussed is IFNG; the disease is hepatocellular carcinoma.