The results have shown the following: (i) there is an association between high B7-H3 expression and poor survival in HCC, which is consistent with previous reports [21–24]; (ii) B7-H3 expression is positively associated with CD8 expression and a Th1/IFNγ gene signature in HCC; and (iii) patients with B7-H3low/CD8high subtype are correlated with favorable survival in HCCs. Here, CD276 is linked to hepatocellular carcinoma.