LCN2 and obesity due to melanocortin 4 receptor deficiency: Other studies have indicated that LCN2 may regulate brown adipose tissue (BAT) to enhance thermogenesis and energy expenditure, because LCN2 loss in mice resulted in compromised adaptive thermogenesis, and potentiated diet-induced obesity, dyslipidemia, fatty liver disease, and insulin resistance [[111], [112], [113]].