PNPLA3 and obesity due to melanocortin 4 receptor deficiency: PNPLA3 rs738409 GG-genotype is related tothe reduction of triacylglycerol and cholesterol concentrations in obese [40] or glucose uncharitable ones [41] as a result of lowered hydrolysis of triacylglycerol and intrahepatic fat aggregation caused by obesity [42].