Unlike NT cells, the majority of surviving TAM cells underwent at least one round of proliferation less than NT transformed cells following RNA silencing of all genes (including EPAS1) and TPL treatment, or even two (figure 7a–e, right panels), In summary, these results show that depletion of some genes overexpressed in response to TPL sensitizes cells to TPL treatment; therefore, these genes are possible targets to enhance the killing effect of TPL on cancer cells. This evidence concerns the gene EPAS1 and cancer.