TCOF1 and Treacher-Collins syndrome: Regarding to the genotype–phenotype correlation, a previous report with a large cohort has proved that although TCOF1 has a LisH domain from exon 1 to 2 and a Treacle domain from exons 2 to 24, the localization of the mutations in the LisH or Treacle domains had no different effects on clinical features or severity of TCS (Vincent et al., 2016).