MSCs exposed to tumor cell‐conditioned medium can differentiate into cancer associated fibroblasts (CAF)71, 72, 73, 74 by TGFβ1‐mediated mechanisms, promoting tumor invasion, epithelial‐mesenchymal transition (EMT), ECM modification, and cancer cell stemness, leading to tumor progression and metastasis.75 This evidence concerns the gene TGFB1 and cancer.