Furthermore, Dong et al found that knockdown of NgBR lead to an overt loss of phosphorylated Akt in human HCC cells (HepG2 and SMMC‐7721) compared with the normal liver cells, but overexpression of NgBR can rescue the impaired phosphorylated Akt levels in human HCC cells.58 The gene discussed is NUS1; the disease is hepatocellular carcinoma.