The result of two PD-L1-positive cases is surprising because PD-L1 expression is reported in up to 40% of melanoma cases, in both primary and metastatic lesions.20,34,35 The data from a recent meta-analysis of multiple solid tumors showed that PD-L1 overexpression is associated with worse disease-free and progression-free survival in melanoma (hazard ratio [HR],  3.39; 95% confidence interval [CI],  2.02–5.69; P < 0.0001).36 Here, CD274 is linked to melanoma.