The topographical pattern of tau tracer retention on PET imaging appears to roughly follow the neuropathological (autopsy) pattern of NFT accumulation [21], in that tau PET tracer retention is usually limited to mesial temporal lobe in clinically normal subjects, but appears to involve the lateral temporal, parietal and frontal lobes in amyloid-positive subjects with increasing degrees of cognitive impairment [22–28]. The gene discussed is MAPT; the disease is Cognitive impairment.