XRCC1 and hepatocellular carcinoma: In another study from Taiwan, it was reported that XRCC1 gene polymorphisms alone did not lead to a statistically significant increase in the risk to develop a hepatocellular carcinoma, whereas the liver cancer risk was significantly enhanced in subjects with a XRCC1 as well as a GSTT1 gene polymorphism (Yu et al. 2003).