TP53 and liver cancer: In this context, it has been reported that polymorphisms affecting the gene coding for the X-ray cross-complementing group 1 (XRCC1) protein was associated with a significant increase in the number of AFB1-DNA adducts in Taiwanese subjects (Lunn et al. 1999) and an increase in liver cancer risk in Taiwanese subjects (Chen et al. 2005), with an increased p53 mutation frequency in codon 249 (Long et al. 2008a) and an increase in liver cancer risk in Chinese subjects (Long et al. 2006) and with an increase in liver cancer risk in Gambian subjects (Kirk et al. 2005).