ICI, immune checkpoint inhibitor; TMB, tumor mutational burden; EGFR, epidermal growth factor receptor; NSCLC, non-small cell lung cancer; TKI, tyrosine kinase inhibitor; ALK, anaplastic lymphoma kinase; PARPi, poly(ADP-ribose) polymerase inhibitors. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.