It is unclear as to why women contain more VGLL3 in their epidermis, although it has been speculated that it may be due to an evolutionary adaption to help develop a stronger immune system and ward off infection, however, at a great cost [15,18]. Due to the increased amount of VGLL3 present on the epidermis through evolutionary adaption, it has left women with an increased autoimmune response, ultimately causing harmful and often life-threatening autoimmune disorders to manifest [18]. Here, VGLL3 is linked to autoimmune disease.