The female predilection of autoimmune disorders follows a bimodal curve as these disorders are more commonly seen in the embryological period or post-menopausal. Evolutionarily, females have a greater amount of VGLL3, which is a unique transcription factor that regulates genes and has a firm association with autoimmune diseases such as Sjogren’s syndrome, SLE, and scleroderma [15]. The gene discussed is VGLL3; the disease is systemic lupus erythematosus.