This case is aimed to report the association of EAATD with thyroid peroxidase (TPO) and thyroid-stimulating immunoglobulin (TSI) antibodies in Grave's disease. We report a 55-year old male who presented with thyrotoxicosis and cerebellar ataxia and was diagnosed with Grave's disease based on clinical and biochemical findings. The patient was managed with anti-thyroid medications with resolution of both thyrotoxicosis and cerebellar symptoms proving the hypothesis that patient's encephalopathy was autoimmune and related to his thyroid disease. This evidence concerns the gene TPO and Encephalopathy.