INS and polycystic ovary syndrome: Studies have shown that MI supplementation is positively correlated with the meiotic progression of germinal vesicle oocytes of the mouse by increasing intracellular Ca2+ oscillation [10]. It is also important to note that the ovary maintains normal sensitivity to insulin despite systematic insulin resistance [36]. In women with PCOS, an increase in insulin leads to the stimulation of ovarian epimerase activity.