Second, pan-cancer co-expression analysis for miRNA-target interaction in HCC using starBase [44] showed that miR-539 level negatively correlated with TAT, HPD, GSTZ1 and FAH expression (r  =  -0.221, r  = -0.193, r  = -0.123, r  = -0.166) (S6 Fig). This evidence concerns the gene HPD and cancer.