Specifically, HPD staining decreased by 2.26-fold ± 2.10 (p = 0.0388), HGD decreased by 1.67-fold ±0.87 (p = 0.0423) and GSTZ1 decreased by 2.27-fold ±1.09 (p = 0.0007) in HCC tumor compared to normal liver tissue (Fig 4). This evidence concerns the gene GSTZ1 and hepatocellular carcinoma.