The major findings of this study are: (1) GLS cut-off values of 7% and 14% obtained from fully automated software stratified the risk of future CD in patients with known or suspected HF; (2) when GLS cut-off values of 7% and 14% and BNP cut-off values of BNP of 100 pg/mL and 200 pg/mL were employed, patients were effectively stratified from low to high risk for future MACEs; (3) automated GLS measurements were significantly and incrementally more powerful than anthropometric factors and blood examination parameters including BNP for predicting future outcomes. The gene discussed is NPPB; the disease is hydrops fetalis.