CHEK2 and breast carcinoma: Comparison between PRR14 genetically altered and unaltered breast cancer samples shows that CHEK2 transcription is reduced (Fig. 6a, P = 0.014) in PRR14 genetically altered breast cancer samples, accompanied by not significantly less protein (Fig. 6b) and significantly less activated form p-CHEK2 (T68) (Fig. 6c, P = 0.038).