PDK1 and neoplasm: This correlate with the down-regulation in the different tumours, and it has been proposed that miR-375 suppresses several oncogenes such as Astrocyte Elevated Gene 1 (AEG-1), Yes-Associated Protein 1 (YAP1), Insulin Like Growth Factor 1 (IGF1R) and Pyruvate Dehydrogenase Kinase Isoenzyme 1 (PDK1)50.