EGFR and neoplasm: In this regard, we have previously shown that activation of hypoxia‐inducible factor (HIF) signalling is closely linked with EGFR-signalling, as HIFs are key survival factors under hypoxic conditions.20 Furthermore, changes in oxygen level have been previously shown to affect NK cell activity as well.21 Together with the findings that hypoxia is frequently seen in most solid tumours,22 it is of crucial importance to take the hypoxic tumour microenvironment into account.