Differential gene expression analysis based on the CSOmap prediction indicated that malignant cells not interacting with T cells show lower levels of class I major histocompatibility complex (MHC) molecules and JUN but higher level of CDK6. These results recapitulate the cancer cell program contributing to resistance of immune checkpoint blockade in melanoma identified recently,32 suggesting the effectiveness of CSOmap in generating valid biological insights. The gene discussed is JUN; the disease is cancer.