It has been recently reported in murine and human melanoma that, compared with CCR2 and CCR5, CXCR3 is necessary for the successful trafficking of tumoricidal T cells across tumor vascular checkpoints,41 consistent with our finding that CXCR3 might mediate the migration of blood T cells into tumor via the CCL5 gradient. The gene discussed is CXCR3; the disease is melanoma.