Since mutations or aberrant expression of SFTPA1 and TLR2 have been associated with pulmonary fibrosis,25,26 the identification of the critical role of SFTPA1-TLR2 in maintaining the normal spatial organization of human alveoli by CSOmap via an unbiased approach further underscores the validity of CSOmap and the molecular insights that it may bring. The gene discussed is SFTPA1; the disease is pulmonary fibrosis.