TLR2 and pulmonary fibrosis: Since mutations or aberrant expression of SFTPA1 and TLR2 have been associated with pulmonary fibrosis,25,26 the identification of the critical role of SFTPA1-TLR2 in maintaining the normal spatial organization of human alveoli by CSOmap via an unbiased approach further underscores the validity of CSOmap and the molecular insights that it may bring.