CD274 and neoplasm: Preclinical studies showed that repeated irradiation at low doses does not induce TREX1 and mediates tumor rejection.95 PD-L1 antibody treatment reversed T cell suppression and showed a synergistic therapeutic effect when combined with radiotherapy.94 Moreover, combining radiotherapy and cGAMP elicited stronger tumor-specific CD8+ T cell responses and showed complete tumor rejection in 70% of mice with implanted tumors.94 Revealing an immunomodulatory role of radiotherapy opens up more possibilities of combining it with other immunotherapies.