After type I IFNs were shown to be associated with CD8+ T cell activation in cancer patients,33 additional studies determined that they stimulated CD8α+ dendritic cells to activate CD8+ T cells.34,35 Several PRRs such as the toll-like receptors (TLRs), RIG-I-like receptors (RLRs), and cGAS can induce type I IFNs upon activation. The gene discussed is CD8A; the disease is cancer.