3.3, we show the nodes having high role A and B motif centrality, such as HIFs, HDAC, BRCA1, EGR1, STAT1, GATA1 and GATA3, and also report their functions as master regulators in liver function, cell proliferation, tumor suppression and genomic stability, etc. as well as stress response. This evidence concerns the gene STAT1 and neoplasm.