To investigate the potential molecular link between Wnt/β-catenin signaling and regulation of the tumor microenvironment in GBMs, we analyzed the expression of Wnt/β-catenin target genes, especially secretory proteins, including CXCL12, DKK1, WISP1, FGF20, and EDN140,41, in GBMs, using the TCGA42 and Gravendeel43 databases. Here, CCN4 is linked to neoplasm.