To study the role of Mir34a in pancreatic cancer development we crossed the Mir34afl/fl mice with the well described Kras mouse model for PDAC38 to generate Ptf1a+/Cre; Kras+/LSL-G12D; Mir34afl/fl mice (hereafter called: KrasG12D; Mir34aΔ/Δ), which were analysed at specific time points. The gene discussed is MIR34A; the disease is familial pancreatic carcinoma.