To study the role of Mir34a in pancreatic cancer development we crossed the Mir34afl/fl mice with the well described Kras mouse model for PDAC38 to generate Ptf1a+/Cre; Kras+/LSL-G12D; Mir34afl/fl mice (hereafter called: KrasG12D; Mir34aΔ/Δ), which were analysed at specific time points. Here, PTF1A is linked to familial pancreatic carcinoma.