Moreover, the segregation of immature (CD101−) and mature (CD101+) neutrophil subsets revealed that mouse tumors treated with X-ray + G-CSF are responsible for a significantly higher fraction of mature neutrophils in the tumor, but not in the blood, when compared with the other groups (X-ray or G-CSF alone) (Supplementary Fig. 31). Here, CSF3 is linked to neoplasm.