By analyzing EPN3 expression (IHC or RT-qPCR) in a large retrospective consecutive cohort (IEO BC 97-00) of ~2400 BCs (Supplementary Tables 1–2)14, we determined that high EPN3 expression was an independent predictor of poor prognosis, in multivariable analysis, associated with a higher risk of distant metastasis (Fig. 10c; Supplementary Table 3). Here, EPN3 is linked to breast cancer.