Scl:Cdx2/Flt3ITD/+ double mutants showed severe thrombocytopenia (Fig. 3e) and succumbed to advanced MPN (Fig. 3b) characterized by splenomegaly (Fig. 3f) and increased in Gr1−positive myeloid cells in PB compared with control or single knockin Cdx2 mice (Fig. 3g). The gene discussed is CDX2; the disease is myeloproliferative neoplasm.