CDX2 and Increased total leukocyte count: Conversely, when Cdx2 expression is restricted to myeloid cells in LysM:Cdx2 mice, there is a more homogeneous phenotype, typified by myelocytic expansion, leukocytosis, and splenomegaly, but without the thrombocytopenia that is hallmark to Scl:Cdx2 mice.