Interestingly, transformed Scl:Cdx2 LKS+ BM cells from acute leukemic mice showed similar or decreased levels of Cebp gene transcripts compared with control cells, with the sole exception of Cebpb (Supplementary Fig. 5f), suggesting these leukemia cells downregulate effectors of myeloid commitment as a mechanism of transformation. The gene discussed is CDX2; the disease is leukemia.