Finally, Cdx2-induced erythro-myeloid leukemia #472 harbored a loss of heterozygosity (LOH) event in the commonly mutated tumor suppressor gene Trp53. To further determine the significance of these SNVs, we confirmed their presence in functional protein domains similar to pathogenic SNVs in human orthologues35 (examples shown in Supplementary Fig. 3a, Supplementary Data 1). This evidence concerns the gene CDX2 and myeloid leukemia.