JAK1 and neoplasm: We found a number of frameshift and non-synonymous somatic mutations in known tumor-associated genes, including positive (Jak1, Raf1, Zap70) and negative regulators (Pten, Cgref1) of signal transduction, cell adhesion molecules (Fat1), transcription factors (Etv6, Ikzf1, Trp53), and DNA-binding proteins (Nabp2) (Supplementary Table 1).