BAP1 and familial pancreatic carcinoma: To study the expression of endogenous Bap1 in a progression model of pancreatic cancer, we established a knockin reporter mouse carrying a lacZ cassette under the control of the endogenous Bap1 promoter flanked by loxP sites to allow tissue-specific deletion following intercrossing with the Pdx1Cre strain27 (Supplementary Fig. 1k).