Meta-analysis of pharmacogenomic data from the Cancer Cell Line Encyclopedia through the CellMinerCDB portal48 revealed that low BAP1 expression correlated with sensitivity to irinotecan (derivative of camptothecin) specifically in human pancreatic cancer cell lines and linear regression analysis among DNA repair genes highlighted BAP1 in explaining the response (Supplementary Fig. 7c, d). Here, BAP1 is linked to familial pancreatic carcinoma.