Principal component and Ingenuity Pathway (IPA) analyses revealed pronounced changes in gene expression and enrichment for pathways regulating cell identity and proliferation (epithelial-to-mesenchymal transition, transforming growth factor-β (TGF-β), and mitogen-activated protein kinase signaling), metabolism and redox homeostasis (AMPK/mammalian target of rapamycin and NRF2 signaling), and DDR (p53, telomerase, and ovarian cancer signaling, which is frequently driven by mutations in BRCA1/2, Fig. 5a, b). This evidence concerns the gene BRCA1 and ovarian carcinoma.