TNF and rheumatoid arthritis: Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease of joints characterised by pain, stiffness, inflammation, and disability.[1] The global prevalence of RA is estimated at 0.5% to 1%, second only to osteoarthritis and gout as major causes of disability.[2] Currently, antirheumatic drugs include glucocorticosteroids, nonsteroidal anti-inflammatory drugs (NSAIDs), disease-modifying antirheumatic drugs (DMARDs), and biological agents (e.g., anti-TNF-therapy).