VEGFA and colorectal carcinoma: Angiogenesis plays a central role in tumor growth and metastasis.[4,8] Tumors require a vascular supply to grow that is achieved via the expression of pro-angiogenic growth factors, including members of the vascular endothelial growth factor (VEGF) family of ligands.[4,9] Tumor progression and poor prognosis in numerous tumor types, including CRC, has been associated with the overexpression of VEGF.