ESR1 and neoplasm: Therefore, she underwent a computed tomography (CT)-guided biopsy at the 11th dorsal vertebral body: the pathological evaluation revealed a bone metastasis of adenocarcinoma sharing immunophenotypic features with ductal carcinoma of the breast (ER 70%, PgR 0%); HER2 and Ki67 were not evaluated due to the paucity of tumor material.