CircRNA cRAPGEF5 plays a role in suppressing RCC via the miR-27a-3p/TXNIP pathway and served as a promising prognostic biomarker and therapeutic target for RCC treatment [13], and circ-AKT3 suppresses ccRCC metastasis by enforcing E-cadherin expression through competitively binding miR-296-3p [14]. The gene discussed is AKT3; the disease is renal cell carcinoma.