We found that IL-1β induction by Fcgr2b−/− BMDMs stimulated with IgG IC was restored to WT levels by the addition of 2DG (Fig. 3F and SI Appendix, Fig. S3D), suggesting that it may potentially ameliorate macrophage-induced inflammation in lupus. This evidence concerns the gene FCGR2B and systemic lupus erythematosus.