FCGR2A and rheumatoid arthritis: In vivo, inflamed NZB/W renal and RA synovial macrophages showed globally similar transcriptional changes to BMDMs stimulated with IgG IC, with an increase in FcγR-inducible genes and a reduction in FcγR-suppressed genes in BMDMs, suggesting that FcγR signaling may underpin the macrophage metabolic phenotype in vivo (SI Appendix, Fig. S1D).