IGHG1 and nephritis: In murine lupus nephritis, there was an increase in Ighg1 expression within NZB/W kidney tissue, consistent with previous reports of local autoantibody production (38) (Fig. 6A), and a positive correlation between Ighg1 transcripts and the expression of a number of nephritis-associated inflammatory mediators (SI Appendix, Fig. S6 A and B), including IL-1β (Fig. 6B), emphasizing the potential importance of glycolysis-associated IL-1β production in mediating autoantibody-associated inflammation in the kidney.