In a subset (Lgr5+) of crypt stem cells, gain of YAP surprisingly displays a tumor-inhibitory role via its cytoplasmic sequestration of disheveled 2 (DVL 2) (Barry et al., 2013) or by inhibiting the activity of the TCF transcriptional complex (Li et al., 2020). The gene discussed is LGR5; the disease is neoplasm.