INS and neoplasm: Yki gut tumor-bearing flies display a systemic wasting syndrome (Kwon et al., 2015) (Fig. 1H; Fig. S2A) and display elevated levels of the insulin antagonist ImpL2 (Fig. 1J) (Kwon et al., 2015), in addition to canonical Yki targets (Fig. 1J) that include Sd (Fig. 1D,J), the DNA-binding partner of Yki (Wu et al., 2008).