The proto-oncogene Yes-associated protein [YAP; Yorkie (Yki) in Drosophila] – the transcription co-factor of the Hippo pathway – interacts with its DNA-binding partner, transcriptional enhanced associate domain 1-4 [TEAD1-4; Scalloped (Sd) in Drosophila] (Wu et al., 2008), and is implicated in cancers (Zanconato et al., 2016). Here, YAP1 is linked to cancer.