Among these 5 genes, APC, TP53, KRAS and PI3KCa are relevant in the tumorigenesis of CRC, whilst KDR encodes for VEGFR2, the main receptor VEGF-A, and its mutational state could be relevant in defining the prognostic role of VEGF-A in CRC patients. Here, TP53 is linked to colorectal carcinoma.