Concerning VEGF-A, tumors exhibiting a detectable, but faint cytoplasmic immunostaining were scored as 1+, tumors displaying a complete cytoplasmic immunostaining with a moderate intensity were scored as 2+, whereas colorectal cancers showing a distinct and intense cytoplasmic immunostaining were scored as strongly positive 3+. The gene discussed is VEGFA; the disease is colorectal cancer.