INS and type 1 diabetes mellitus: Indeed, it seems that patients with T1D have a decreased insulin sensitivity in liver tissue (defined in the HEC as a decreased insulin-stimulated suppression of endogenous glucose production), and an increased IR in muscle (observed in the HEC as a lower whole-body glucose disposal even in the presence of lower intrahepatic fat content) and in adipose tissue (observed due impaired insulin-mediated suppression of lipolysis with subsequent increase of free fatty acids and glycerol levels) [6, 32], in comparison with healthy controls.