There were a negative correlation only between EN2 and PTEN in 25 PC tissues (R = -0.399, P = 0.048) (Fig. 5c) and a positive correlation only between EN2 and VEGF in 25 BPH tissues (R = 0.47, P = 0.019) (Fig. 5d). This evidence concerns the gene EN2 and pachyonychia congenita.