IFNA1 and discoid lupus erythematosus: We drew on a resource of multi-cohort gene expression meta-analyses for 103 diseases [42, 43] to identify genes with reproducible evidence of differential expression in eleven diseases characterized by an elevated IFN transcriptional signature [8], including viral infections, systemic and discoid lupus erythematosus, rheumatoid arthritis, sarcoidosis, and Sjogren’s syndrome.